Table 1.
Effect of geraniol and geranylgeraniol on the growth inhibitory and the membrane damaging activity of farnesol against S. aureus FDA209P.
| Terpene | Ratioa | DPb (h) | Leakage of K+ ionsc)(x 10-9 mol μg-1) | Initial rate alcohol of leakagec) (x 10-10 mol μg-1 sec-1) |
|---|---|---|---|---|
| Farnesol + geraniol | 1 : 0 | 13.8 | 267 | 8.8 |
| 1 : 1 | 13.5 | 271 | 11.1 | |
| 1 : 2 | 14.5 | 395 | 13.2 | |
| 1 : 4 | 16.3 | 186 | 3.1 | |
| 1 : 8 | 29.0 | 173 | 2.4 | |
| 1 :16 | 43.7 | N.T. d | N.T. d | |
| Farnesol+geranylgeraniol | 1 : 0 | 13.8 | 267 | 8.8 |
| 1 : 1 | 17.2 | 28 | 1.1 | |
| 1 : 2 | 14.3 | 27 | 0.8 | |
| 1 : 4 | 11.3 | 33 | 0.8 | |
| 1 : 8 | 7.7 | 15 | 0.3 | |
| 1 :16 | 6.3 | N.T.d | N.T.d |
a Concentration of farnesol was set at 5 and 10 μg mL-1 when the growth inhibitory and the leakage of K+ ions in response to mixed terpenes was observed, respectively; b delay in proliferation; c Assays were performed in triplicate. Results are shown as mean values; d not tested.