Table 1.

Anticonvulsant activity of diazepam and the newly synthesized compounds.

Comp.	Mean convulsion threshold ± S.E	% Protection	% Potency
Control	2.33 ± 027	0	0
Diazepam	7.11 ± 0.33*	205.42*	--
4a	3.00 ± 0.27	28.76	42.19
4b	4.67 ± 0.27*	100.43*	65.68*
5a	2.45 ± 0.31	5.15	34.45
6	4.00 ± 0.41	71.67	56.25
7a	2.33 ± 0.14	0	0
7b	5.17 ± 0.50*	121.89*	72.71*
7c	5.33 ± 0.18*	128.76*	74.96*
7d	4.33 ± 0.45*	85.84*	60.90*
7e	4.50±0.20*	93.13*	63.29*
7f	8.17 ± 0.77*	250.64*	114.90*
8a	4.33 ± 0.41*	85.84*	60.90*
8b	4.17 ± 0.23	78.97	58.64
8c	3.67 ± 0.32	57.51	51.61
8d	4.17 ± 0.23	78.97	58.64
8e	3.33 ± 0.32	42.92	46.83
9a	3.50 ± 0.34	50.21	49.22
9b	5.17 ± 0.34*	121.89*	72.71*

Values represent means of six animals' ± standard error.

* P≤ 0.05 statistically significant from control group (using Dunnett's test as post hoc test)