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. 2017 May 31;38(7):728–737. doi: 10.1093/carcin/bgx049

Figure 2.

Figure 2.

LTA4H mediates cell transformation. (A) JB6 P+ or (B) HaCaT cells expressing the indicated shRNAs were grown in soft agar and then colonies were counted. (C) JB6 P+ or (D) HaCaT cells were transfected with the indicated constructs and grown in soft agar and then colonies were counted. For A–D, data are shown as mean values ± SD (*P < 0.05). (E) All animals (n = 25) were administered 200 nmol of DMBA and then treated with vehicle or 200 nmol of TPA twice a week for 21 weeks. Data are shown as mean values ± SEM and statistical significance was determined by one-way ANOVA (*P < 0.05).