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. 2018 Mar 14;39(5):669–680. doi: 10.1093/carcin/bgy043

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Figure 3. — Overview of DNA methylation level changes. (A) Methylation level of gene substructures in control, AOM+DSS and AOM+DSS+Curcumin groups. (B) Box plots showing the distribution of DMRs in control, AOM+DSS and AOM+DSS+Curcumin groups. Only DMRs with >12 CpG sites were included in this analysis to ensure comparability and analytical robustness. Differences between groups were not significant. P-values, Mann–Whitney. (C) Venn diagram showing the number of DMRs within promoter regions in the comparisons of control versus AOM+DSS and AOM+DSS versus AOM+DSS+Curcumin. (D) Venn diagram showing the number of DMRs in all genomic locations except distal intergenic regions, in the comparisons of control versus AOM+DSS and AOM+DSS versus AOM+DSS+Curcumin. Methylation ratio of DMRs from both comparisons is shown in heatmap for all three groups.