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Mapping of trophoblast-specific transcriptional activity. Chimeric HLA-A/HLA-C core promoter constructs representing all combinations of the 5´, central, and 3´ regions were tested in 293T, BeWo, and JAR cells. The activity of core HLA-C and HLA-A constructs is shown for comparison. The average activity of each construct shown is relative to the activity of the empty pGL3 vector in at least 4 independent experiments. Error bars represent +/− SEM.
