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. 2018 Nov 26;138(22):2499–2512. doi: 10.1161/CIRCULATIONAHA.118.034942

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© 2018 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 6. — Effects of statin treatment and genetic inhibition of PCSK9 on polar metabolites. Differences in metabolite levels due to statin treatment were assessed 6 months post randomization in the PROSPER (Prospective Study of Pravastatin in the Elderly at Risk) trial (black). The corresponding effects of PCSK9 rs11591147-T were assessed for n=72 185. Error bars indicate 95% confidence intervals. Glycine, glucose, lactate, pyruvate, and glycerol measures were not available from PROSPER. Results are shown in SD-scaled concentration units (top axis) and relative to the lowering effect on low-density lipoprotein cholesterol (LDL-C; bottom axis).