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Pegaptanib aptamer. Proposed secondary structure model of the pegaptanib aptamer is indicated on the left. All pyrimidines were 2’-fluoromodified during selection procedure. All purines of the aptamer were 2’-O-methyl-modified after the selection. Additionally 40 kDa polyethylene glycol was added in 5’-end and an inverted 3’-3’-deoxythymidine cap in 3’ the end. Chemical structure of indicated modifications is shown on the right [57,74].
