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. Author manuscript; available in PMC: 2019 Oct 2.
Published in final edited form as: Structure. 2018 Aug 23;26(10):1360–1372.e5. doi: 10.1016/j.str.2018.07.004

Figure 3: Double mutant cycle analysis of NS3/4A protease inhibitors.

Figure 3:

ΔΔG for each inhibitor used in the enzyme inhibition assay against the Y56H/D168A double substitution (black) and the sum of each single substitution (green). The substitutions Y56H and D168A show a coupled effect for grazoprevir, paritaprevir and AM-07. However, these substitutions are additive for danoprevir and to a lesser extent for 5172-mcPlP3 and JZ01–15. See also Table S3.