Table 1.
Cytotoxic activitya of compounds 1–6 against four cancer cell lines.
| Compound | Cytotoxic activity (IC50, µg/mL) | |||
|---|---|---|---|---|
| HuCCA-1 | HepG2 | A549 | MOLT-3 | |
| 1 | 36.0 | 31.5 | 30.0 | 25.83 |
| 2 | 35.0 | 16.0 | 30.0 | 0.72 |
| 3 | 25.0 | 17.5 | 24.0 | 0.088 |
| 4 | 0.03 | 4.75 | 0.04 | 0.004 |
| 5 | 5.5 | 11.75 | 3.6 | 0.77 |
| 6c | NDb | NDb | NDb | NDb |
| Etoposided | NDb | 16.0 | NDb | 0.024 |
| Doxorubicine | 0.35 | 0.23 | 0.38 | NDb |
a Cancer cell lines are: HuCCA-1 Human cholangiocarcinoma cancer cells; HepG2 Human hepatocellular liver carcinoma cell line; A549 Human lung carcinoma cell line; and MOLT-3 Human lymphoblastic leukemia cell line; b ND = Not determined; c insoluble in DMSO;
d,e Etoposide and doxorubicin were used as the reference drugs.