Table 2.

HIV-1 IN inhibitory potency of various 3',4'-dihydroxystyrylquinolines.

Compd.Nb						3’-Processing IC50 (μM)	References
	R5	R6	R7	R8	X
21	H	H	H	H	CH	>100.0	14
22	H	H	H	OH	CH	7.4	14
20	H	H	H	OH	N	57.0	24
23	H	H	H	OAc	CH	>100.0	14
24	H	H	H	NO2	CH	>100.0	14
25	H	H	H	NH2	CH	>100.0	14
26	H	H	H	CO2H	CH	>100.0	25
27	CO2H	H	H	H	CH	>100.0	25
28	H	CO2H	H	H	CH	>100.0	25
29	H	H	CO2H	H	CH	>100.0	25
30	CO2H	H	CO2H	H	CH	>100.0	25
31	OH	CO2H	H	H	CH	>100.0	19
32	CO2H	H	H	OH	CH	7.0	19