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Influence of the ancillary ring on the HIV-1 IN inhibitory potency of 8-hydroxy-2-styryl-quinoline-7-carboxylic acids.
|
In vitro Biological activity | Reference | ||
|---|---|---|---|---|
| Compd. nb. | R | 3’-Processing IC50(μM) | Strand Transfer IC50 (μM) | |
| 77a |
|
5.3 | 2.1 | 14 |
| 77b |
|
1.9 | 5.1 | 26 |
| 77c |
|
3.4 | 3.0 | 26 |
| 77d |
|
4.0 | 11.0 | 26 |
| 77e |
|
1.6 | untested | 26 |
| 77f |
|
2.2 | 3.5 | 26 |
| 77g |
|
1.2 | 1.7 | 26 |
| 77h |
|
3.4 | 31.0 | 26 |
| 77i |
|
5.0 | untested | 25 |
| 77j |
|
39.0 | 30.0 | 30 |
| 77k |
|
>100.0 | untested | 30 |
