Table 3.
Entry | Aryl 1 | Aryl 2 | Product | Yield % |
---|---|---|---|---|
1 | 4-MeO-Ph- | 4-Cl-Ph- | 8 | 55 |
2 | 4-MeO-Ph- | Ph- | 9 | 64 |
3 | 4-MeO-Ph- | 4-F-Ph- | 10 | 43 |
4 | 4-MeO-Ph- | 2-Tolyl- | 11 | 50 |
5 | 4-MeO-Ph- | 3-CF3-Ph- | 12 | 57 |
6 | 4-Cl-Ph- | 4-MeO-Ph- | 13 | 54 |
7 | 4-Cl-Ph- | Ph- | 14 | 62 |
8 | 4-Cl-Ph- | 4-F-Ph- | 15 | 57 |
9 | 4-Cl-Ph- | 2-Tolyl- | 16 | 58 |
Reaction conditions: arylboronic acid (2 equiv.), Pd(PPh3)4 (2.5 mol %), Na2CO3 (3 equiv.), DMF/ethanol (9 : 1), MW 300 W, 150 °C, 3 h