Figure 5.

The consensus sequence and amino acid distribution of NTD^p24 in 131 Gag/PR chimeric viruses. For each NTD^p24 position, the HXB2 index is shown at the top, followed by the NTD^p24CA interface, corresponding consensus amino acid, and prevalence of particular residues. The NTD^p24CA–NTD^p24CA interface and the NTD^p24CA–CTD^p24CA interface (distance < 5 Å) are marked in green and yellow, respectively. The interface residues making the hydrogen bond are in dark green (NTD^p24CA–NTD^p24CA) and brown (NTD^p24CA–CTD^p24CA). The symbols in colour denote the Ank^GAG1D4 binding pocket residues. The bullets, diamonds, and boxes are the binding residues in the complexes of Ank^GAG1D4 bound to helix 1, those bound to helix 7, and those binding both helices, respectively. The corresponding consensus amino acid was defined by the most prevalent of the particular residues. Polymorphisms with proportions ≥5% are indicated using blue superscripts, and red otherwise. The amino acids in the blue box are alternative characters of the key residues interacting with Ank^GAG1D4, whereas the amino acids in the red box are variable residues.