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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
RNA virus mutational spectrum. As RNA viruses mutate, the sequence space is sampled to find areas of higher fitness. This space is hypothesized to be unstable, so it is best for mutation-prone RNA viruses to exist in flatter areas of this space where decreases in fitness are slight.