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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Neuroscience. 2018 Sep 11;391:25–49. doi: 10.1016/j.neuroscience.2018.09.002

2.

2.

Kainate receptor (KAR)-mediated currents in cultured olfactory bulb (OB) neurons isolated with KAR agonists (kainate or SYM 2081) and an AMPA receptor (AMPAR) antagonist (SYM 2206). A) Kainate activated a large nondesensitizing (square) current in some OB cells, consistent with a significant AMPAR contribution to the current. B) However, a strongly desensitizing current was seen in other cells, consistent with a significant KAR contribution to the current. C) Coapplication of the selective KAR agonist, SYM 2081, and SYM 2206 produced a prominent current in these cells. D) Same as “C” but with pretreatment with SYM 2206, reflecting the timing for the onset of the effects of SYM 2206 in blocking AMPARs. E) Coapplication of kainate and SYM 2206 after pretreatment with SYM 2206. F) Application of SYM 2206 during a current evoked by application of kainate. SYM 2206 blocked the AMPAR-mediated portion of this current, revealing the relatively large KAR-mediated component of the current. G) Currents evoked by sequential application of kainate and kainate +SYM 2206.