Table 1.

In vitro cytotoxicity and cytostatic activity of the cinchona derivatives on human tumor cell cultures.

	Cell line
	HepG2	SH-SY5Y	HL-60	MCF-7
Compd.	Cytotoxicity (IC50a in µM)
1	>100	>100	>100	> 100
2	33.10 ± 3.04	29.80 ± 4.24	37.70 ± 3.67	25.32 ± 4.60
3	0.72 ± 0.01	0.78 ± 0.02	1.70 ± 0.05	0.75 ± 0.02
4	4.24 ± 1.12	0.82 ± 0.54	0.86 ± 0.02	21.70 ± 3.23
5	>100	>100	6.70 ± 0.02	>100
6	17.60 ± 0.25	21.20 ± 3.24	32.20 ± 4.67	>100
7	3.34 ± 1.02	0.84 ± 0.02	1.80 ± 0.56	5.34 ± 1.78
8	8.90 ± 0.23	1.50 ± 0.02	2.30 ± 0.05	>100
	Cytostatic effect (IC50 in µM)
1	>100	>100	>100	> 100
2	65.00 ± 6.70	80.70 ± 5.78	41.90 ± 1.45	56.00 ± 4.56
3	0.40 ± 0.17	0.99 ± 0.10	0.76 ± 0.01	1.00 ± 0.34
4	3.40 ± 0.12	1.30 ± 0.54	0.94 ± 0.02	5.10 ± 0.67
5	>100	>100	6.50 ± 3.56	21.80 ± 3.18
6	65.60 ± 3.40	82.90 ± 6.78	>100	82.90 ± 7.98
7	4.60 ± 0.02	4.20 ± 2.30	10.20 ± 1.65	3.89 ± 1.18
8	19.60 ± 2.12	17.20 ± 3.45	4.50 ± 0.01	2.36 ± 0.01

^a The 50% inhibitory concentration (IC₅₀) values were determined from the dose-response curves. The curves were defined using Microcal^TM Origin1 (version 7.5) software.