Figure 7.

The suggested model of relationships among BCR-ABL1, MYC, MYB, PU.1, miR-150 and miR-155 in CD34⁺ and CD34⁻ cells from chronic myeloid leukemia (CML) patients and healthy donors. The schemes represent the expression levels and mutual relationships among the molecules in CD34⁺ (A) and CD34⁻ (B) cells from healthy donors compared with the profiles of CD34⁺ (C) or CD34⁻ (D) cells, respectively, from CML patients at diagnosis. The circle sizes denote the expression levels of specific molecules. The black lines represent the active stimulatory (arrowheads) or inhibitory (flat-heads) relationships described in the manuscript. The red line emphasizes the novelty mechanism of miR-150 repression by MYC in CML CD34⁺ cells. By the dashed lines we outlined regulations that we assumed based on published observations.^{15,17,18,24,25,27}