Table 2.

HCCP-mediated formation of quinazoline thioethers from quinazolin-4(3H)-ones ^a.

Entry	Quinazolin-4(3H)-one		ArSH	Product		Yield (%) b
1		1a			3	79
2	1a				4	64 c
3	1a				5	69
4	1a				6	59
5	1a				7	50
6	1a				8	86
7	1a				9	94
8	1a				10	66
9	1a				11	91
10		1b			12	54 d
11		1c			13	60
12		1d			14	64
13		1e			15	51 d
14		1f			16	79
15		1g			17	72

^aReagents andConditions: 1 (0.5 mmol), HCCP (1.1 equiv.), DIPEA (5.0 equiv.), MeCN (5 mL), rt, activation time (1 h), then thiophenols (5.0 equiv.), 45 °C, 23 h; ^b Isolated yield; ^cm-CH₃PhSH (6.0 equiv.); reaction time (48 h); ^d Activation time (20 h).