Table 1.
Anti-plasmodial activity against Plasmodium falcipurum (CQS) D10 strain (in vitro) and Plasmodium berghei (in vivo).
| Sample | a IC50 (µg/mL) | b Average % parasitemia | b Average % suppression | a Cytotoxicity (μg/mL) | |
|---|---|---|---|---|---|
| HEK293 | HepG2 | ||||
| M. caffra (leaves) | 2.14 | NT | NT | ||
| M. obtusifolia (bark) | 32.5 | NT | NT | ||
| H. colchicifolia (bulb) | NA | NT | NT | ||
| Ursolic acid | 6.8 | NT | NT | ||
| Ursolic acid acetate | 1.9 | 0.07 | 94.01 | 366.00 | 566.09 |
| 3-oxo-ursolic acid | 7.3 | NT | NT | ||
| Taraxerol | >100 | NT | NT | ||
| Sawamilletin | >100 | NT | NT | ||
| Artesunate | 5.1 * | NT | NT | ||
| Chloroquine | 14.1 * | 0.07 | 83.43 | ||
* = ng/mL, a IC50 = Inhibitory concentration, b Average percentage parasitemia/suppression (in vivo), NT = not tested, NA = not active.