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. 2012 Dec 21;18(1):140–153. doi: 10.3390/molecules18010140

Figure 2.

Figure 2

(A) Effect of compounds 4a–5f on the hydrolytic activity of BACE1. (B) The hydrolytic activity of BACE1 as function of enzyme concentrations at different concentrations of compound 5a. (C and F) Mechanistic analysis of the inhibition of BACE1 by sulfonamide chalcones 4a and 5a. (C and D) Lineweaver-Burk plots for the inhibition of compounds 4a and 5a on the hydrolytic activity of BACE1. (Inset) Km values as a function of the concentrations of 4a and 5a. Dependence of the values of Vmax on the concentration of 4a and 5a. (E and F) Dixon plots for the inhibition of compounds 4a and 5a on BACE1 catalyzed proteolysis of substrate.