Table 4.

Pharmacokinetic parameters of sildenafil in group 5 and 6.

Parameters	t1/2 (min)	C0 (μg/mL)	AUC (min μg/mL)	Cl (mL/min/kg)	Vss (L/kg)
Group 5	55 ± 17	3.3 ± 1.3	108 ± 34	111 ± 70	6540 ± 3760
Group 6	69 ± 17	9.4 ± 1.9 **	440 ± 106 **	73 ± 23	4790 ± 510

Group 5, high dose Epimedium sagittatum extract (2 g/kg/day) for 3 consecutive days and on day 4^th + low dose sildenafil (10 mg/kg); group 6, high dose Epimedium sagittatum extract (2 g/kg/day) for 3 consecutive days and on day 4^th + high dose sildenafil (30 mg/kg). Data are expressed as mean ± S. D. (n = 6). ** Intergroup difference between group 5 and other groups