Table 1.

Antimycobacterial activity of salicylanilide 4-(trifluoromethyl)benzoates 1.

				MIC [μmol/L]
	R1	R2		Mtb. 331/88		M. avium 330/88			M. kansasii 235/80					M. kansasii 6509/96
				14 d	21 d	14 d		21 d	7 d		14 d	21 d		7 d		14 d	21 d
1a	4-Cl	3-Cl		2	4	8		16	0.5		2	4		2		8	8
1b	5-Cl	3-Cl		4	4	8		8	1		4	4		2		8	8
1c	4-Cl	4-Cl		2	2	4		8	1		2	2		1		4	4
1d	5-Cl	4-Cl		4	4	4		8	1		4	4		1		4	4
1e	4-Cl	3,4-diCl		1	1	4		4	1		2	4		1		2	4
1f	5-Cl	3,4-diCl		1	2	2		8	1		2	4		1		2	4
1g	4-Cl	3-Br		1	2	2		8	2		4	4		1		4	4
1h	5-Cl	3-Br		4	8	8		16	4		8	8		2		8	8
1i	4-Cl	4-Br		2	2	8		8	1		4	8		2		8	8
1j	5-Cl	4-Br		2	4	8		8	1		4	4		2		4	4
1k	4-Cl	3-F		8	8	16		32	8		16	16		8		16	16
1l	5-Cl	3-F		4	4	8		16	4		8	8		8		8	16
1m	4-Cl	4-F		8	8	16		32	4		16	16		8		16	16
1n	5-Cl	4-F		4	8	4		4	2		8	8		4		8	8
1o	4-Cl	4-CF3		1	1	1		4	1		2	2		1		2	2
1p	5-Cl	4-CF3		2	2	2		8	2		2	4		1		4	4
1q	4-Cl	3-CF3		2	2	4		16	2		4	8		1		4	8
1r	4-Br	4-CF3		1	1	2		4	1		2	4		1		2	4
INH				0.5–1	0.5–1	≥250	≥250		>250		>250	>250		2–4		4–8	8–16
PAS				62.5	62.5	32		125	125		1000	>1000		32		125	500
CF3-BA				>1,000	>1,000	>1,000		>1,000	1,000		>1,000	>1,000		250		1,000	1,000

INH = isoniazid; PAS = p-aminosalicylic acid; CF₃-BA = 4-(trifluoromethyl)benzoic acid; Two best MICs for each strain are given in bold.