Table 3.
ICL inhibition activity of salicylanilide 4-(trifluoromethyl)benzoates 1.
| R1 | R2 | % ICL inhibition at 10 μmol/L (± standard deviation) | |
|---|---|---|---|
| 1a | 4-Cl | 3-Cl | 18 ± 1.9 |
| 1b | 5-Cl | 3-Cl | 13 ± 1.7 |
| 1c | 4-Cl | 4-Cl | 12 ± 2.7 |
| 1d | 5-Cl | 4-Cl | 12 ± 2.3 |
| 1e | 4-Cl | 3,4-diCl | 18 ± 1.5 |
| 1f | 5-Cl | 3,4-diCl | 17 ± 1.6 |
| 1g | 4-Cl | 3-Br | 27 ± 0.2 |
| 1h | 5-Cl | 3-Br | 21 ± 1.8 |
| 1i | 4-Cl | 4-Br | 18 ± 1.2 |
| 1j | 5-Cl | 4-Br | 14 ± 4.0 |
| 1k | 4-Cl | 3-F | 25 ± 0.8 |
| 1l | 5-Cl | 3-F | 20 ± 0.5 |
| 1m | 4-Cl | 4-F | 23 ± 1.4 |
| 1n | 5-Cl | 4-F | 17 ± 1.3 |
| 1o | 4-Cl | 4-CF3 | 13 ± 1.2 |
| 1p | 5-Cl | 4-CF3 | 17 ± 2.3 |
| 1q | 4-Cl | 3-CF3 | 19 ± 0.5 |
| 1r | 4-Br | 4-CF3 | 23 ± 0.1 |
| 3-NP | 25 ± 4.1 | ||
| INH | 0 | ||
INH = isoniazid; 3-NP = 3-nitropropionic acid; Inhibition rate values comparable to 3-NP or higher are given in bold.