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Antileishmanial activity and cytotoxicity of selected compounds.
| Compound | L.major amastigotes IC50 (µM) | Cytotoxicity BMDM IC50 (µM) | Selectivity index SI a |
|---|---|---|---|
| 1 | 47.6 | 5.3 | 0.1 |
| 7 | 47.0 | 10.9 | 0.2 |
| 15 | 10.9 | 54.3 | 5.0 |
| 2 | 39.2 | 49.0 | 1.2 |
| 19 | 49.1 | >148 | >3.0 |
| 20 | 19.5 | >126 | >6.4 |
| 10 | 54.1 | 9.8 | 0.2 |
| Miltefosine | 33.0 | 65.5 | 2.0 |
a SI = IC50 for BMDM/IC50 for L. major.
