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Kinases are shown as secondary structure cartoons representations (grey). Common structural features are colour coded as follows: PSTAIRE/helix αC, yellow; activation loop (T-loop), red; hinge region, green; Gly-rich loop (P-loop), blue. The gate-keeper residue in represented in CPK (Corey-Pauling-Koltun) sticks. The three modelled structures are (a) GSK3β (b) ERK2 and (c) CDK5/p25, p25 depicted in orange.
