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. 2014 Apr 30;19(5):5634–5649. doi: 10.3390/molecules19055634

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© 2014 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

β-Asarone treatment promotes hippocampal neuronal neurogenesis in CUMS-exposed rats. Rats were orally treated with β-asarone (25 mg/kg per day) or saline for 28 days while being exposed to CUMS or control conditions. (A) Representative photomicrographs depicting the distribution of newly born cells (i.e., BrdU⁺ cells) in the subgranular zone-granule cell layer of hippocampi from rats. (B) Histograms of the number of BrdU-positive cells in the subgranular zone-granule cell layer of hippocampi from rats. Data were presented as mean ± S.D., n = 6 per group. *, p < 0.05 compared with no stress/saline animals; ∫, p < 0.05 compared with CUMS/saline animals (analysis of variance and SNK post hoc test).