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. 2014 Apr 30;19(5):5634–5649. doi: 10.3390/molecules19055634

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© 2014 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

β-Asarone increases BDNF expression in hippocampus of CUMS-exposed rats. Rats were orally treated with β-asarone (25 mg/kg per day) or saline for 28 days while being exposed to CUMS or control conditions. (A) BDNF protein levels were determined by immunoblot analysis with antibody against BDNF. GAPDH served as a loading control. A representative immunoblot for BDNF and GAPDH. (B) The graph demonstrates the densitometric analysis of BDNF protein expression (normalized to GAPDH). (C) Total RNA was isolated from hippocampus using RNAiso reagent and used for cDNA synthesis. The mRNA levels BDNF was detected by real-time PCR and the 2^−ΔΔCt method. Data were presented as mean ± S.D., n = 6 per group. *, p < 0.05 compared with no stress/saline animals; ∫, p < 0.05 compared with CUMS/saline animals (analysis of variance and SNK post hoc test).