Table 4.
Cytokines produced by hPBMCs after exposure to 2 k chitin purified from hyphae.
| Cytokine | C. albicans (n = 7) | A. fumigatus (n = 16) | M. circinelloides (n = 16) | |
|---|---|---|---|---|
| IL-6 | control | 65 (55) | 61 (49) | 61 (49) |
| chitin | 394 (922) | 105 (209) | 1681 (1419) | |
| p | 0.383 | 0.428 | 0.0004 | |
| IL-1β | control | 40 (0) | 40 (0) | 40 (0) |
| chitin | 195 (410) | 61 (58) | 898 (1081) | |
| p | 0.456 | 0.158 | 0.006 | |
| TNFα | control | 41 (4) | 50 (17) | 50 (17) |
| chitin | 137 (254) | 47 (14) | 545 (1063) | |
| p | 0.361 | 0.6 | 0.082 | |
| IL-10 | control | 12 (5) | 16 (10) | 16 (10) |
| chitin | 16 (14) | 12 (8) | 66 (120) | |
| p | 0.475 | 0.469 | 0.119 | |
Chitin preparation (number of independent replicates); Mean (standard deviation); Values are given in pg/mL.