Scheme 1.
Synthesis of the 2-aryl-6,8-dibromo-2,3-dihydroquinazolin-4(1H)-ones 3a–d.
| R1 | R2 | R3 | % Yield 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 3a | H | H | H | 85 | |||||
| 3b | -CH3 | H | H | 60 | |||||
| 3c | H | -CH3 | H | 83 | |||||
| 3d | H | -CH3 | -CH3 | 63 | |||||
Reagents and conditions: (i) I2 (cat.), toluene, reflux, 12 h.
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