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Luciferase assays. (A) Dose-response curves of native (AE1), TL modified (AE2, AE3, AE4) and PS modified (AES2, AES3, AES4) siRNAs. n = 3 ± SD; (B) Plot of RNAi activity of native (AS1P), 3′-end modified (AS2P) and scrambled (AS3P) single-stranded antisense siRNAs (ss-siRNA) 5′-phosphorylated. For experimental conditions see the Experimental Section. ns = p > 0.05; *** = p < 0.001. n = 3 ± SD.
