Figure 4.

Effects of oligomers on stereotypical behaviors. Forty-five or forty-six-week-old SAMP8 mice were administered vehicle (Veh, water p.o., n = 4), while another two groups were administered oligomers orally at doses of 10 mg/kg body weight/day (O (10), n = 4) using a stomach tube until death. For the remaining group of mice, the mean food intake was restricted to 60% until death (FR, n = 4). SAMR1 mice (Cont, 45–46 weeks old, n = 4) were used as a control group. One hundred and thirty-nine days after the start of administration, actions of rearing up on the hindlimbs and jumping from the bottom of the cage were counted for 15 min (A, B). The time spent hanging from the lid was measured for 10 min (C). Administration was continued during the tests. ^a p = 0.0034 (Student’s t-test); * p < 0.05 (One-way ANOVA, post-hoc Bonferroni’s test).