Figure 6.

Effects of oligomers on spatial memory deficit in SAMP8. Eighteen-week-old SAMP8 were administered vehicle (Veh, water p.o., n = 6; closed circles) or oligomers (10 mg/kg body weight/day, p.o., n = 6; open squares or 100 mg/kg body weight/day, p.o., n = 5; closed squares) for 5 weeks. SAMR1 were used as a control (Cont, n = 5; open circles). Fifteen days after the start of administration, memory acquisition tests were continued for 6 days in a Morris water maze. Administration was continued during the tests. Escape latencies to a hidden platform were measured (A). The swimming velocities of mice in the memory acquisition test are shown (B). Thirty-eight-week-old SAMP8 were administered vehicle (Veh, water p.o., n = 7) or oligomers (O (10), 10 mg/kg body weight/day, p.o., n = 7 or O (50), 50 mg/kg body weight/day, p.o., n = 7). Age-matched SAMR1 were used as a control (Cont, n = 7). Twenty-eight days after administration started, an object location test was performed. The preference index was defined as the number of times a mouse made contact with any one of the objects (training session) or the moved object (test session) out of the total number of times the mouse made contact with both objects (%) (C). * p < 0.05 vs. Veh. (A and B: Repeated measures two-way ANOVA followed by Dunnett’s or Bonferroni’s post-hoc test); * p < 0.05 (C: One-way ANOVA followed by Bonferroni’s post-hoc test); ^a p = 0.0005; ^b p = 0.0213 (C: paired t-test).