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. 2014 Sep 17;19(9):14862–14878. doi: 10.3390/molecules190914862

Table 2.

Immunosuppressive activity of hinokinin (1).

Cytokine Production Ratio a LTI d
TNF-α IL-12 IL-10 IL-6c
Hinokinin (1) 0.36 b 0.44 b 0.37 b 25.94 ± 1.02
77.5 c 20.5
LPS b 1 1 1
Prednisolone b 0.6 0.2 0.41
Dexamethasone 9.17 ± 0.53

a Cytokine production ratios were expressed as ratios to cytokine production induced by LPS; b Hinokinin tested at 10 μg/mL, Prednisolone tested at 0.3 μg/mL [81]; c IC50 values are given in μg/mL [83]; d Lymphocyte transformation inhibition, IC50 given in μg/mL [82].