Figure 1.

Structures of the sulfated small molecules screened for human plasmin inhibition. The library includes 55 molecules belonging to diverse chemical classes of chalcones (compounds 1–10), flavonoids (11–16), sucrose octasulfate (17), quinazolinones (18 and 19), tetrahydroisoquinolines (20–27), flavonoid-quinazolinone heterodimers (28–34), bis-quinazolinone homodimers (35–47), and bis-flavonoid homodimers (48–55). The sulfated molecules also differed in the number of sulfate groups (1–8/molecule) as well as their spatial orientation.