Table 4.

Pharmacokinetic parameters of diazepam and dexamethasone to rats with and without hypoxia (n = 6).

Parameter	Diazepam		Dexamethasone
	Normoxia	Hypoxia	Normoxia	Hypoxia
Cmax (ng/mL)	5.3 ± 1.6	39.2 ± 4.3 **	121 ± 31.1	65.7 ± 13.9 **
Tmax (h)	0.30 ± 0.11	3.1 ± 2.6 *	1.3 ± 0.57	2.17 ± 0.931
k	0.38 ± 0.077	0.27 ± 0.18	0.21 ± 0.063	0.072 ± 0.027 **
MRT (h)	2.3 ± 0.51	6.5 ± 2.2 **	4.3 ± 1.2	9.14 ± 3.44 *
t1/2 (h)	4.2 ± 3.7	3.3 ± 1.4	3.5 ± 0.94	11.5 ± 6.6 *
AUC0→72 (ng/mL∙h)	13.0 ± 4.3	326 ± 39.6 **	656 ± 141	750 ± 232

Data are given as the mean ± SD; * p < 0.05 and ** p < 0.01 showed significantly different between the normoxic and hypoxic groups.