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Bioactivities of compounds 9a–i.
| Compound | IC50 a (μM) | ||
|---|---|---|---|
| EZH2(AlphaLISA) | HCT15 | MDA-MB-231 | |
| 9a | 8.40 ± 0.34 | 10.9 ± 0.35 | 14.6 ± 2.24 |
| 9b | 18.4 ± 1.65 | >20 | >20 |
| 9c | 20.1 ± 0.85 | >20 | >20 |
| 9d | 5.60 ± 0.45 | 8.60 ± 2.20 | 12.4 ± 0.95 |
| 9e | 6.70 ± 0.36 | 10.6 ± 0.83 | 12.5 ± 0.62 |
| 9f | 9.20 ± 0.51 | 15.5 ± 0.53 | 12.4 ± 0.49 |
| 9g | 17.8 ± 2.07 | 15.9 ± 1.85 | >20 |
| 9h | 14.9 ± 1.71 | 19.8 ± 1.27 | 13.2 ± 1.64 |
| 9i | 13.7 ± 1.32 | >20 | >20 |
a Values are means of at least three measurements.
