Table 1.

The antiproliferative activity (IC₅₀ ^a μM) of synthetic hybrids 10a–i against selected cell lines ^b.

Compound	Bel-7402	L-02	K562	MGC-803	CaEs-17
1	7.48 ± 0.32	18.3 ± 0.8	4.76 ± 0.32	5.69 ± 0.39	11.0 ± 1.0
9	16.0 ± 1.1	26.4 ± 1.3	2.64 ± 0.19	5.84 ± 0.57	23.7 ± 1.8
7a	22.0 ± 0.8	37.8 ± 1.3	22.6 ± 2.0	25.4 ± 1.5	24.3 ± 0.9
7b	22.3 ± 1.6	39.6 ± 1.4	24.2 ± 2.5	22.2 ± 2.5	25.7 ± 1.4
7c	19.6 ± 1.0	41.3 ± 2.9	22.6 ± 1.7	24.6 ± 1.4	23.8 ± 1.0
7d	17.8 ± 1.4	37.4 ± 0.8	17.5 ± 1.4	18.5 ± 0.8	19.8 ± 1.3
7e	18.6 ± 0.8	36.3 ± 2.1	18.5 ± 1.6	20.0 ± 1.1	18.7 ± 1.0
7f	16.7 ± 0.8	35.8 ± 1.3	17.5 ± 1.0	19.3 ± 0.6	19.2 ± 0.7
7g	22.7 ± 1.0	39.4 ± 2.6	24.0 ± 1.4	20.6 ± 1.7	25.7 ± 0.7
7h	21.3 ± 0.7	35.4 ± 1.4	24.5 ± 1.4	23.5 ± 1.0	22.9 ± 1.4
7i	22.4 ± 1.6	37.9 ± 2.8	23.0 ± 1.2	21.6 ± 1.5	24.8 ± 1.5
10a	1.91 ± 0.09	24.4 ± 0.8	2.86 ± 0.05	2.84 ± 1.12	5.68 ± 0.53
10b	1.75 ± 0.12	22.1 ± 1.3	2.90 ± 0.17	2.67 ± 0.24	5.56 ± 0.06
10c	1.01 ± 0.04	31.2 ± 1.2	1.97 ± 0.18	1.60 ± 0.15	4.02 ± 0.14
10d	1.17 ± 0.02	27.4 ± 1.0	2.04 ± 0.10	2.03 ± 0.15	4.84 ± 0.47
10e	1.12 ± 0.09	29.3 ± 0.9	2.02 ± 0.17	1.91 ± 0.09	4.04 ± 0.23
10f	0.81 ± 0.06	29.9 ± 1.4	1.73 ± 0.04	1.18 ± 0.10	3.77 ± 0.30
10g	1.85 ± 0.11	33.9 ± 1.5	2.82 ± 0.22	2.80 ± 0.09	5.52 ± 0.08
10h	1.65 ± 0.12	29.8 ± 0.9	2.78 ± 0.20	2.65 ± 0.16	5.48 ± 0.21
10i	1.09 ± 0.09	27.7 ± 1.3	2.06 ± 0.16	1.64 ± 0.12	4.13 ± 0.29
Taxol	1.89 ± 0.09	3.73 ± 0.17	0.41 ± 0.02	4.65 ± 0.29	0.43 ± 0.03

^a Results are expressed as mean ± S.D. of three independent experiments. ^b IC₅₀: concentration that inhibits 50% of cell growth.