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Plasma concentrations of clozapine (CLZ, A), norclozapine (norCLZ, B), and clozapine N-oxide (CLZ N-oxide, C) over time in rats treated with an intraperitoneal dose of 10 mg/kg of CLZ alone (n = 5), or pretreated orally with Radix Rehmanniae (RR; n = 4), Fructus Schisandrae (FS; n = 6), Radix Bupleuri (RB; n = 6), and Fructus Gardeniae (FG; n = 4), respectively. The data are presented as mean ± SEM.
