Table 2.
Saponins with anti-obesity activity.
| Saponin | Plant Species | Study | Action | Reference |
|---|---|---|---|---|
| Platycodin A (1) | Platycodon grandiflorum (Jacq.) A.DC. | In vitro | Lipase inhibition | [71] |
| Platycodin C (2) | Platycodon grandiflorum (Jacq.) A.DC. | In vitro | Lipase inhibition | [71] |
| Deapioplatycodin D (3) | Platycodon grandiflorum (Jacq.) A.DC. | In vitro | Lipase inhibition | [71] |
| Platycodin D (4) | Platycodon grandiflorum (Jacq.) A.DC. | In vitro In vivo | Lipase inhibition, AMPK activation, prevention of abdominal fat accumulation | [71,72] |
| Momordin Ic (5) | Kochia scoparia (L.) Schard | In vitro | Lipase inhibition | [73] |
| Escin Ia (6) | Aesculus turbinata Blume | In vitro | Lipase inhibition | [74] |
| Escin IIa (7) | Aesculus turbinata Blume | In vitro | Lipase inhibition | [74] |
| Escin Ib (8) | Aesculus turbinata Blume | In vitro | Lipase inhibition | [74] |
| Escin IIb (9) | Aesculus turbinata Blume | In vitro | Lipase inhibition | [74] |
| Mogroside IV(10) | Siraitia grosvenorii C. Jeffrey | In vitro | Lipase inhibition | [75] |
| Mogroside V (11) | Siraitia grosvenorii C. Jeffrey | In vitro | Lipase inhibition | [75] |
| Silphioside F (12) | Acanthopanax senticosus (Rupr. et Maxim.) Harms | In vitro | Lipase inhibition | [76] |
| Copteroside B (13) | Acanthopanax senticosus (Rupr. et Maxim.) Harms | In vitro | Lipase inhibition | [76] |
| Gypsogenin 3-O-β-d-glucuronide (14) | Acanthopanax senticosus (Rupr. et Maxim.) Harms | In vitro | Lipase inhibition | [76] |
| Sessiloside (15) | Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem | In vitro | Lipase inhibition | [77] |
| Chiisanoside (16) | Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem | In vitro | Lipase inhibition | [77] |
| Damulin A (17) | Gynostemma pentaphyllum Makino | In vitro | AMPK activation | [78] |
| Damulin (18) | Gynostemma pentaphyllum Makino | In vitro | AMPK activation | [78] |
| Foenumoside B (19) | Lysimachia foenum-graecum Hance | In vitro In vivo | AMPK activation, reduction of body weight gain | [79] |
| Soyasapogenol B (20) | Korean fermented soy food named cheonggukjang | In vitro | AMPK activation | [80] |
| Dioscin (21) | Several species | In vitro | Influence on AMPK/MAPK | [81] |
| Trillin (22) | Dioscorea nipponica Makino | In vivo | Antihyperlipidemic activity | [82] |
| Ginsenoside Rb1 (23) | Ginseng | In vivo | Modulation of serum levels of PYY and NPY | [67] |