Treatment (mg/kg; i.p.) | Time(min) | Seizure Phase (%) | Number of Mice | |||
---|---|---|---|---|---|---|
Clonus | Tonus | Death | ||||
Vehicle | Saline | 30 | 100 | 100 | 75 | 8 |
OJe | 20 | 30 | 100 | 87.5 | 75 | 8 |
40 | 30 | 75 | 37.5 ** | 37.5 ** | 8 | |
80 | 30 | 75 | 50 * | 75 | 8 | |
100 | 30 | 50 * | 25 ** | 25 ** | 8 | |
120 | 30 | 25 ** | 0 ** | 0 ** | 8 | |
40 | 60 | 100 | 75 | 75 | 8 | |
40 | 120 | 100 | 100 | 100 | 8 | |
HES | 40 | 30 | 100 | 87.5 | 75 | 8 |
80 | 30 | 100 | 50 * | 50 * | 8 | |
100 | 30 | 62.5 | 25 ** | 25 ** | 8 | |
120 | 30 | 25 ** | 12.5 ** | 0 ** | 8 | |
40 | 60 | 100 | 100 | 87.5 | 8 | |
40 | 120 | 100 | 100 | 87.5 | 8 | |
NRTN | 40 | 30 | 100 | 100 | 75 | 8 |
80 | 30 | 100 | 75 | 75 | 8 | |
100 | 30 | 87.5 | 50 * | 50 * | 8 | |
120 | 30 | 62.5 | 25 ** | 37.5 ** | 8 | |
40 | 60 | 100 | 100 | 100 | 8 | |
40 | 120 | 100 | 100 | 100 | 8 | |
HES + NRTN | 120 + 120 | 30 | 37.5 ** | 12.5 ** | 12.5 ** | 8 |