Table 1.

Inhibition of ChEs activity and self-induced Aβ (1–42) aggregation.

	Compound	IC50 (nM) AChE a	IC50 (nM) BuChE b	Selectivity Index c	Aβ (1–42) Aggregation Inhibition (%) d
	8a	306.5 ± 12.4	202.9 ± 35.7	0.660	26.1 ± 4.5
	8b	90.3 ± 7.3	119.7 ± 12.5	1.326	19.5 ± 2.7
	8c	52.7 ± 8.2	215.4 ± 33.7	4.087	18.5 ± 4.0
	8d	61.7 ± 5.2	106.9 ± 13.1	1.733	37.2 ± 0.9
	8e	184.1 ± 15.2	195.7 ± 3.5	1.059	35.1 ± 3.2
	tacrine	151.1 ± 10.3	27.6 ± 7.3	0.182	n.t. e
	curcumin	n.t.	n.t.	n.t.	37.3 ± 1.2
	ferulic acid	n.t.	n.t.	n.t.	36.5 ± 3.6

^a Inhibitor concentration (mean ± SD of three independent experiments) required for 50% inactivation of AChE. ^b Inhibitor concentration (mean ± SD of three independent experiments) required for 50% inactivation of BuChE. ^c Selectivity index = IC₅₀ (BuChE)/IC₅₀ (AChE). ^d Inhibition of self-induced Aβ (1–42) aggregation, the thioflavin-T fluorescence method was used, the mean ± SD of at least three independent experiments and the measurements were carried out in the presence of 20 μM compounds. ^e n.t. = not tested.