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. 2016 Jan 12;21(1):75. doi: 10.3390/molecules21010075

Table 4.

The proportion of drugs containing only aromatic rings, only non-aromatic rings, both aromatic and non-aromatic rings, no rings and bridge rings in the whole database and five sub-databases.

Classes a Only Aromatic Rings Only Non-Aromatic Rings Both Aromatic and Non-Aromatic Rings No Rings Bridge Rings
All drugs 37.5 (12.1, 16.5) b 12.4 42.0 (11.1, 11.8) c 5.8 2.4
Oral drug 36.9 (11.1, 15.9) b 11.1 45.2 (11.6, 12.4) c 4.1 2.3
CNS drugs 31.7 (8.8, 18.3) b 7.0 53.6 (12.0, 17.4) c 5.3 2.4
Cardiovascular drugs 42.0 (14.1, 17.3) b 7.3 45.3 (12.8, 12.3) c 3.6 1.7
Anti-infective drugs 37.8 (10.5, 17.3) b 15.9 41.5 (13.0, 11.9) c 3.3 1.4
Anti-cancer drugs 30.1 (9.5, 7.7, 7.9) d 13.3 43.7 (6.6, 6.8, 5.0) e 11.1 1.8

a The captions in each row represent drugs containing different rings; b The numbers in brackets represents the proportions of drugs with one aromatic ring and two aromatic rings, sequentially; c The numbers in brackets represents the proportions of drugs with one aromatic ring and one non-aromatic ring, two aromatic rings and one non-aromatic ring, sequentially; d The numbers in brackets represents the proportions of drugs with one aromatic ring, two aromatic rings and three aromatic rings, sequentially; e The numbers in brackets represents the proportions of drugs with two aromatic rings and one non-aromatic ring, two aromatic rings and two non-aromatic rings, two aromatic rings and three non-aromatic rings, sequentially.