. 2016 Jan 12;21(1):75. doi: 10.3390/molecules21010075

Table 5.

The percentages of drugs containing different categories of functional groups in the whole database and five sub-databases.

Functional Groups	All Drugs			Oral Drug			CNS Drugs			Cardiovascular Drugs			Anti-Infective Drugs			Anti-Cancer Drugs
Functional Groups	1 ^a	2 ^a	>2 ^a	1 ^a	2^a	>2 ^a	1^a	2^a	>2 ^a	1^a	2^a	>2 ^a	1^a	2^a	>2 ^a	1^a	2^a	>2 ^a
-F	5.4	1.6	0.4	6.8	2.1	0.4	9.2	2.0	0	2.9	1.2	0.2	6.4	2.0	1.2	6.6	1.6	0.2
-CF₃	2.5	0.2	0.1	2.8	0.4	0	3.9	0.4	0.1	2.3	0.1	0.2	0.9	0.1	0	1.8	0	0
-CN	2.4	0.2	0	2.1	0.5	0	2.0	0	0	3.8	0.3	0	2.0	0.3	0	1.1	0.5	0
-NO₂	2.0	0.1	0	3.3	0.1	0	1.5	0	0	2.5	0	0	5.1	0.8	0	2.0	0.5	0
-NH₂	9.3	1.1	0.5	11.1	1.2	0	6.8	0.5	0	7.1	0.3	0	23.2	2.7	2.5	17.6	3.2	0.5
-OH	20.0	7.2	6.1	19.1	6.2	6.5	14.0	2.9	1.2	24.1	6.2	4.8	19.0	7.2	13.3	14.3	11.3	15.8
-SH	0.3	0	0	0.5	0.1	0	0.1	0	0	0.5	0	0	0	0	0	0.2	0	0
-CHO	0.7	0	0	0.7	0	0	0.2	0	0	0.4	0	0.1	1.9	0	0	0.7	0	0
-COOH	12.9	1.7	0.3	16.8	1.0	0.1	3.6	0.6	0.2	12.3	2.2	0	26.9	2.5	0.1	7.7	2.7	0.9
-CONHOH	0.2	0	0	0.4	0	0	0.1	0	0	0.1	0	0	0	0.1	0	1.1	0	0
-COOR	16.1	3.6	1.0	14.1	4.5	0.8	9.4	1.3	0.2	14.7	7.6	2.0	13.6	3.5	1.3	13.1	3.8	4.8
-CONH₂	3.5	0.1	0.1	4.5	0.1	0	5.5	0.4	0	3.0	0.2	0	5.2	0	0	3.4	0	0
-SO₃H	0.7	0.2	0	0.3	0.2	0	0.2	0.3	0	0.3	0	0	1.2	0.3	0.1	0.2	0	0
-SO₂NH₂	1.3	0.1	0	2.6	0.1	0	0.7	0	0	0.7	0	0	0.9	0.1	0	0.7	0	0

^a “1, 2, 3, > 3” in row represent the number of functional groups.