Table 1.
The solubility parameters and solubility parameter differences (δ) of PVPK30 and the three studied molecules. The solubility parameters were used in predicting the polymer/drugs miscibility.
| Solubility Parameter Comparison | ||||||
|---|---|---|---|---|---|---|
| Polymer/Drugs | Hansen’s 3D Method | Van Krevelen Method | Hoy’s Method | Average | Difference (δ) | Classification |
| PVPK30 | 21.57 | 22.18 | 22.95 | 22.23 | ||
| Haloperidol | 23.09 | 25.15 | 22.47 | 23.57 | 1.34 | Miscible |
| Droperidol | 23.63 | 25.09 | 23.39 | 24.04 | 1.80 | Miscible |
| Deshydroxyhaloperidol | 20.90 | 22.68 | 21.69 | 21.76 | 0.48 | Miscible |