Table 2.
MICs of tebipenem pivoxil and other antibiotics against the tested Gram-negative bacteria.
| Strain | MIC50/MIC90 (μg/mL) | |||
|---|---|---|---|---|
| Tebipenem Pivoxil | Meropenem | Imipenem and Cilastatin | Ceftriaxone | |
| Escherichia coli | ≤0.125/1 | ≤0.125/1 | 0. 25/1 | 64/>128 |
| Klebsiella pneumoniae | ≤0.125/0.5 | ≤0.125/1 | 0.5/4 | 2/>128 |
| Enterobacter cloacae | ≤0.125/1 | ≤0.125/2 | 0.25/2 | 128/>128 |
| Enterobacter aerogenes | ≤0.125/≤0.125 | ≤0.125/0.25 | 0.5/2 | 0.5/32 |
| Citrobacter freundii | ≤0.125/0.25 | ≤0.125/0.25 | ≤0.125/0.5 | 64/>128 |
| Acinetobacter baumannii | 16/64 | 32/64 | 64/128 | 128/>128 |
| Stenotrophomonas maltophilia | 32/64 | 32/128 | >128/>128 | >128/>128 |
| Pseudomonas aeruginosa | 8/64 | 2/32 | 16/128 | 128/>128 |
| Serratia marcescens | ≤0.125/16 | ≤0.125/32 | 2/64 | 8/>128 |
| Haemophilus influenzae | ≤0.125/0.25 | ≤0.125/0.5 | ≤0.125/1 | 2/16 |
| Proteus mirabilis | ≤0.125/≤0.125 | ≤0.125/0.5 | ≤0.125/0.5 | 16/64 |