Table 6.

ED_50s of tebipenem pivoxil in various sepsis models.

Strain	Dose (mg/kg)	Survival Number	ED50 (mg/kg)	95% CI (mg/kg)
ATCC29213	50.0	10	7.0281	4.8242~10.2389
	25.0	9
	12.5	7
	6.25	7
	3.13	1
Staphylococcus aureus clinical strain	100.0	10	18.6414	12.1759~28.5401
	50.0	7
	25.0	6
	12.5	4
	6.25	2
	3.13	0
ATCC10031	25	10	5.3265	3.6176~7.8426
	12.5	8
	6.25	4
	3.125	3
	1.56	1
	0.78	0
Klebsiella pneumoniae clinical strain	25	10	2.3205	1.6219~3.3201
	12.5	9
	6.25	9
	3.125	7
	1.56	7
	0.78	0
ATCC29522	6.25	10	1.5529	1.0720~2.2496
	3.125	8
	1.56	5
	0.78	2
	0.39	0
Escherichia coli clinical strain	12.5	10	3.0932	2.1156~4.5224
	6.25	8
	3.125	4
	1.56	3
	0.78	0
ATCC27853	100	10	20.8060	14.7041~29.4400
	50	9
	25	7
	12.5	3
	6.25	0
Pseudomonas aeruginosa clinical strain	100	10	20.6961	14.3390~29.8717
	50	9
	25	6
	12.5	4
	6.25	0