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. 2016 Jun 22;21(6):806. doi: 10.3390/molecules21060806

Figure 4.

Figure 4

Comparing residues lining the active site of G. hybrida 2-PS and M. sativa CHS. (A) 2-PS catalyzes the condensation of acetyl-CoA with two units of malonyl-CoA to form 6-methyl-4-hydroxy-2-pyrone; (B) the structures of 2-PS (pink, PDB ID: 1QLV) and CHS (blue, PDB ID: 1CGK) were aligned to compare the active site cavity between the two structures. The presence of the three bulkier residues in 2-PS (L202, L261, and I343) show that a tetraketide such as naringenin will not fit inside the active site. Thus, only a smaller polyketide, such as 6-methyl-4-hydroxy-2-pyrone, may be formed.