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Crystal structure of human IL-11 (PDB entry 4MHL [20]). α-Helices A to D are labelled. Dashed lines mark the non-resolved regions. The residues comprising the proposed sites for IL-11 interaction with IL-11Rα (site I, green) and gp130 (site II, yellow; site III, grey) receptors [20] are indicated. The residues not conserved in either macaque or mouse IL-11 are shown in cyan (see Figure S1).
