Abstract
In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the incident radiation caused by the action of the polyphenol on the artificial membrane lipid matrix.
Key words: Gossypol and its derivatives, Lipid membranes, Differential scanning calorimetry, Membrane fluidity
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Abbreviations used
- AOA
antioxidant activity
- DMPC
dimyristoylphosphatidylcholine
- DPH
1,6-diphenyl-1,3,5-hexatriene
- DPPC
dipalmitoyl-phosphatidylcholine
- DSC
differential scanning calorimetry
- PC
phosphatidylcholine
- PE
phosphatidylethanolamine
- PVP
N-polyvinylpyrrolidone (8000 MM)
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