Abstract
In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.
Keywords: STAG1/PMEPA1, IL-8, E-cadherin, Prostate cancer cell line
Full Text
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Abbreviations used
- DHT
5α-dihydrotestosterone
- IL-8
interleukin-8
- PSA
prostate specific antigen
- STAG1
solid tumor associated gene 1
- STR
short tandem repeat
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